hdac3 inhibitor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T36575	HDAC3 Inhibitor
	HDAC3 inhibitor is an allosteric inhibitor of histone deacetylase 3 (HDAC3; Ki = 0.16 nM). It is selective for HDAC3 over HDAC1 and HDAC2 (IC50s = 0.95, 11.81, and 95.45 nM, respectively, using recombinant HDACs). In add...
T24131	HDAC3-IN-T247	HDAC3 inhibitor T247,HDAC3 inhibitor-T247,HDAC3 IN T247,T247	Histone Demethylase , Antiviral
	HDAC3-IN-T247 (HDAC3 inhibitor T247) is a selective and potent histone deacetylase 3 (HDAC3) inhibitor with anticancer and antiviral activities.HDAC3-IN-T247 induces NF-κB acetylation in human colon cancer HCT116 cells i...		Histone Demethylase , Antiviral
T10255	AES-135		HDAC
	AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 (IC50s: 654, 190, and 636 nM) with anti-tumor activity.		HDAC
T5347	CXD101	CXD-101	HDAC
	CXD101 is a novel class I-selective HDACi (HDAC1 (IC50 : 63nM), HDAC2 (IC50 :570nM), HDAC3 (IC50 :550nM)). CXD101(CXD-101) has no activity against HDAC class II		HDAC
T24132	HDAC3-IN-T326	HDAC3 inhibitor-T326,T326,HDAC3 IN T326,HDAC3 inhibitor T326,HDAC3INT326
	HDAC3-IN-T326 is a potent and selective HDAC3 inhibitor that acts by increasing NF-κB acetylation and activating HIV gene expression in latent HIV-infected cells.
T8233	BRD3308		Apoptosis , HIV Protease , HDAC
	BRD3308 is a highly selective inhibitor of HDAC3(IC50 of 54 nM), attenuating PE-mediated phosphorylation of ERK but not JNK.		Apoptosis , HIV Protease , HDAC
T6481	Droxinostat	NS 41080	Apoptosis , HDAC
	Droxinostat (NS 41080) is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3 and no inhibition to HDAC1, 2, 4, 5, 7, 9, and 10.		Apoptosis , HDAC
T6286	RGFP966 (E-isomer)		HDAC
	RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC.		HDAC
T3516	EDO-S101	Tinostamustine,Minomustine	HDAC
	EDO-S101 (Tinostamustine) is a pan HDAC inhibitor with IC50 values of 9, 9 and 25 nM for HDAC1, HDAC2 and HDAC3 , respectively.		HDAC
T4389	SR-4370	SR 4370	HDAC
	SR-4370 is an HDAC inhibitor. SR- 4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp.		HDAC
T6639	RG2833	RGFP109	HDAC
	RG2833 (RGFP109) (RGFP109), a brain-penetrant HDAC inhibitor, is with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively.		HDAC
T1762	RGFP966	RGFP 966	HDAC
	RGFP966 is an HDAC3 inhibitor (IC50: 0.08 μM) and does not affect other HDACs at concentrations up to 15 µM.		HDAC
T6233	Entinostat	SNDX-275,MS-275	Apoptosis , HDAC , Autophagy
	Entinostat (MS-275) (MS-275) is an inhibitor of HDACs that inhibits HDAC1 and HDAC3 (IC50s: 0.18/0.74 μM).		Apoptosis , HDAC , Autophagy
T6279L	Givinostat hydrochloride	ITF2357 hydrochloride,Givinostat HCl,ITF2357,ITF 2357,ITF-2357,ITF2357 HCl	HDAC
	Givinostat hydrochloride (ITF2357 hydrochloride) is an inhibitor of HDAC with IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat hydrochloride exhibits anti-inflammatory, anti-angiogenic, and antineopla...		HDAC
T2294	BG45		Apoptosis , HDAC
	BG45 is an HDAC I type inhibitor with IC50 of 289 nM, 2.0 μM, 2.2 μM and >20 μM for HDAC3/1/2/6 in cell-free assays, respectively.		Apoptosis , HDAC
T30579	BRD4097		HDAC
	BRD4097, a negative control in the HDAC1/2/3/8 assay, is a selective histone deacetylase (HDAC3) inhibitor that can be used to protect b-cells and improve insulin resistance, help promote cognitive function and enhance l...		HDAC
T6362	Domatinostat	4SC202,4SC 202,4SC-202 (free base),4SC-202	Apoptosis , HDAC
	Domatinostat (4SC202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (L...		Apoptosis , HDAC
T67878	HDAC-IN-52		HDAC
	HDAC-IN-52 is a pyridine-containing HDAC inhibitor that inhibits HDAC1, HDAC2, HDAC3 and HDAC10 with IC50s of 0.189, 0.227, 0.440 and 0.446 μM, respectively. HDAC-IN-52 can be used in cancer research.		HDAC
T26897	BRD2492		HDAC
	BRD2492 is a selective and potent dual inhibitor of HDAC1 and HDAC2 with potential anticancer, antitumour and antiproliferative activities, inhibiting HDAC1/2, HDAC3 and HDAC6.BRD2492 inhibits the growth of breast cancer...		HDAC
T4370	Resminostat hydrochloride	4SC-201 hydrochloride,RAS2410 hydrochloride	HDAC
	Resminostat hydrochloride (RAS2410 hydrochloride) is an effective inhibitor of HDAC1/HDAC3/HDAC6 (IC50: 42.5/50.1/71.8 nM), respectively, and shows less potent activities against HDAC8 (IC50: 877 nM).		HDAC